Neuroendocrine tumors (NETs) are a rare form of cancer with just 5-6 new cases per 100,000 individuals diagnosed each year.1 NETs originate in neuroendocrine cells and often develop slowly over several years. Healthy neuroendocrine cells are part of both the endocrine and the nervous system and can be found throughout the body. These cells release neurotransmitters, cell messengers or hormones into the blood controlling how our body works, meaning they play a key role in the interaction between the nervous and endocrine system.
75 % of all neuroendocrine tumors are from gastroenteric or pancreatic origin.2 They are called gastroenteropancreatic neuroendocrine tumors (GEP-NETs) and are found in the digestive system. GEP-NETs are often asymptomatic and challenging to diagnose. This is why they are often diagnosed at a late stage with metastases and limited possibility of surgery. GEP-NETs appear predominantly in patients aged 50-60 with women being approximately 2.5 times more often affected than men.3 In some cases GEP-NETs can secrete various hormones and are then referred to as functioning GEP-NETs.
Healthy neuroendocrine cells have somatostatin receptors on their surface. The neurotransmitter somatostatin regulates the endocrine system within normal body function by binding to these receptors according to the lock and key principle. Tumor cells of neuroendocrine origin often express an increased number of these somatostatin receptors on their surface, showing a unique tumor characteristic that differs from that of healthy neuroendocrine cells.4
Neuroendocrine tumors are often detected via PET/CT (Positron Emission Tomography / Computerized Tomography) or SPECT (Single Photon Emission Computed Tomography) diagnostic imaging techniques. Surgery is the main treatment for NETs. Sometimes, though, NETs can spread to other parts of the body or may not be completely removable during surgery. In this case different treatment options are available, such as chemotherapy or targeted therapy. Targeted Radionuclide Therapy is a therapeutic approach for neuroendocrine tumors being investigated in COMPETE.
1 Bryan Oronsky et al., December 2017, Neoplasia Vol. 19, pp. 991-1002
2 Pape et al., 2000, Der Onkologe 6: 624–633
3 Bryan Oronsky et al., December 2017, Neoplasia Vol. 19, pp. 991-1002
4 Papotti et al., 2002, Virchows Archiv 440(5): 461-75